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Antisynthetase syndrome
Anti-synthetase syndrome is a rare medical syndrome associated with interstitial lung disease, dermatomyositis, and polymyositis and other autoimmune diseases.
==Signs and symptoms==
As a syndrome, this condition is poorly defined. Diagnostic criteria require one or more antisynthetase antibodies (which target tRNA synthetase enzymes), and one or more of the following three clinical features: interstitial lung disease, inflammatory myopathy, and inflammatory polyarthritis affecting small joints symmetrically. Other supporting features may include fever, Raynaud's phenomenon and "mechanics hands"-thick, cracked skin usually on the palms and radial surfaces of the digits.〔A man with fevers, arthrhalgias, and pulmonary infiltrates, L Christopher-Stine et al. NEJM 367: 2134-2147.〕
The disease, rare as it is, is more prevalent in women than in men. Early diagnosis is difficult, and milder cases may not be detected. Also, interstitial lung disease may be the only manifestation of the disease. Severe disease may develop over time, with intermittent relapses.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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